Fanconi's anemia: current questions about its pathogenesis, clinical manifestations, diagnosis and treatment

Abstract

The Fanconi's anemia is a constitutional aplastic anemia with autosomal recessive inheritance. A polymalformative picture and a chromosomal instability with tumor high-risk is added to medullary hypoplasia. This disease is very interesting by all this facts and because
it is the most frequent aplastic anemia in childbood. The present article is a general review summarizing the main aspects about its pathogenesis, clinical manifestations, diagnosis and treatment, but the recent genetic aspects and their prognostic and therapeutic
implications are speciaiiy underlined.